A Merkel cell carcinoma arising in the ear that was thought to be a squamous cell carcinoma.
A Merkel cell carcinoma arising on the eye in an 80 year old woman that was thought to be a stye.
Arrow (click to view) indicates a firm, enlarged, elevated lymph node (ink shows edges of firmness noted on physical exam), into which MCC tumor cells had spread. Darker area on upper right side of MCC lesion represents site of biopsy.
This MCC contained the Merkel cell polyomavirus. MCCs in sun-protected areas are more likely to be driven by the virus than MCCs arising on sun-exposed skin. (Mutational landscape of MCPyV-positive and MCPyV-negative merkel cell carcinomas with implications for immunotherapy.
MCCs are more likely to arise on the left side, likely in part because of greater UV-exposure to the left side when driving.
The tumor has some features of a wart, but on closer examination the skin surface is quite smooth and blood vessels are enlarged and visible, features that would not be very common for a wart.
The tumor developed in an area of extensive sun damage. This lesion is a Merkel cell carcinoma and squamous carcinoma (SCC) “collision tumor,” meaning the two tumors are directly adjacent to each other. Collision tumors such as this are caused by sunlight and are almost always negative for the Merkel cell polyomavirus.
The abdomen is a relatively sun protected area but MCC can develop in these areas also. The square-shaped rash around the tumor is a reaction to a bandage. There are cherry angiomas (blue circles), that are 2-3mm red bumps scattered on the abdomen. Cherry angiomas are common benign skin lesions (blood vessel growths) that are unrelated to the MCC.
The authoritative source on Merkel cell carcinoma.
June 26, 2017